“Starting from the important study by Glantz et al (2000), discuss and critically analyse how decreased dendritic spine density on prefrontal cortical pyramidal neurons could contribute to pathophysiology in schizophrenia. In addition, debate whether more recent findings complement or support the hypothesis that reduced dendritic spine number contributes to the pathophysiology of schizophrenia.” Glantz, L. A., & Lewis, D. A. (2000). Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Archives of general psychiatry, 57(1), 65-73. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/481552